I went from 257 lbs to 207 lbs in one summer.
No drugs, no supplements, nothing.
Run 45 mins a day hard, no bread, no superfluous sugars, no pasta, no sweets, no dessert, lotsa vegetables and lots of water.
All of the supplements will have adverse effects on the human body in the future, whether they are noticeable or not. I wouldn't touch any supplement unless it was a direct and 100% pure extract from something 100% purely natural.
Willpower is more effective than any drug or supplement, and if you have it, you are already thinner, time just needs to pass